郁书怀,副研究员,硕士生导师。毕业于新捕京3522com食品科学与工程专业,博士期间赴美哈佛大学化学与化学生物系进行联合培养。研究方向为食品生物技术,主要利用分子生物学、结构生物学、生物信息学致力于食品酶挖掘、开发利用与分子改造功、功能优化方面的研究。以第一作者在ACS Catalysis(IF:13.084)、Journal of Agricultural and Food Chemistry(IF:5.279)等期刊发表论文10余篇。现任《食品研究与开发》期刊青年编委。
工作和教育背景
2019.1-今副研究员,新捕京3522com,新捕京3522com
2015.9-2018.12博士,新捕京3522com,食品科学与工程专业
2010.9-2013.6硕士,新捕京3522com,食品科学
2006.9-2010.6学士,合肥工业大学,食品科学与工程专业
研究方向
食品生物技术,食品酶技术,酶工程及应用技术,食品加工技术
1、国家自然科学基金青年基金(31901630):基于loop区调控机制的双果糖酐水解酶分子改造研究,2020.01-2022.12,主持;
2、江苏省基础研究计划(自然科学基金)-青年基金(BK20190583):酶法高效合成菊二糖的定向进化及机制研究,2019.07-2022.06,主持;
3、新捕京3522com基本科研计划-青年基金(JUSRP12007):双果糖酐水解酶高效合成菊二糖研究,2020.01-2021.12,主持;
1、Yu, S.;Shen, H.; Cheng, Y.; Zhu, Y.; Li, X.; Mu, W., Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue.ACS Catalysis2018,8(11), 10683–10697 [IF=/szdw/fjs1/Y/ /13.084]
2、Yu, S.;Wang, Y.; Tian, Y.; Xu, W.; Bai, Y.; Zhang, T.; Mu, W, Highly efficient biosynthesis of α-arbutin from hydroquinone by an amylosucrase fromCellulomonas carboniz.Process Biochemistry2018,68, 93-99 [IF=/szdw/fjs1/Y/ /3.757]
3、Yu, S.;Zhang, Y.; Zhu, Y.; Zhang, T.; Jiang, B.; Mu, W., Improving the catalytic behavior of DFA I-forming inulin fructotransferase fromStreptomyces davawensiswith site-directed mutagenesis.Journal of Agricultural and Food Chemistry2017, 65(34), 7579-7587 [IF=/szdw/fjs1/Y/ /5.279]
4、Yu, S.;Zhu, Y.; Zhang, T.; Jiang, B.; Mu, W., Facile enzymatic production of difructose dianhydride III from sucrose.RSC Advances2016, 6(105), 103791-103794 [IF=/szdw/fjs1/Y/ /3.361]
5、Yu, S.;Wang, X.; Zhang, T.; Jiang, B.; Mu, W., Probing the role of two critical residues in inulin fructotransferase (DFA III-producing) thermostability fromArthrobactersp 161mfsha2.1.Journal of Agricultural and Food Chemistry, 2016, 64, 6188-6195 [IF=/szdw/fjs1/Y/ /5.279]
6、Yu, S.; Zhou, C.; Zhang, T.; Jiang, B.; Mu, W., Short communication: 3-Phenyllactic acid production in milk byPediococcus pentosaceusSK25 during laboratory fermentation process.Journal of Dairy Science2015, 98, 813-817 [IF=4.034]
7、Yu, S.; Zhu, L.; Zhou, C.; An, T.; Zhang, T.; Jiang, B.; Mu, W., Promising properties of a formate dehydrogenase from a methanol-assimilating yeastOgataea parapolymorphaDL-1 in His-tagged form.Applied Microbiology and Biotechnology2014, 98, 1621-1630 [IF=/szdw/fjs1/Y/ /4.813]
8、Zeng, A; Yang, R;Yu, S.*, Zhao, W*, A novel hypoglycemic agent: polysaccharides from laver (Porphyraspp.).Food & Function2020,11(10), 9048-9056 [IF=5.396]
9、Yan, J, Yang, R,Yu, S.*, Zhao, W*, The application of the lytic domain of endolysin fromStaphylococcus aureusbacteriophage in milk.Journal of dairy science2020, Epub Dec 23. [IF=/szdw/fjs1/Y/ /4.034]